Adolescent AFIX: A Multi-state Randomized Control Trial to Increase Adolescent Immunization by Facilitating Vaccine Providers' Adoption of Best Practices

Year: 2013
Funding: NNPHI PHS3 Award
Status: Completed

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This multi-state randomized controlled trial aims to address low HPV vaccination coverage among adolescents by enhancing a systems intervention now used with a quarter of the nation's vaccine providers. The modified intervention uses quality improvement measures and ongoing feedback for providers who treat adolescent patients in primary care settings. The specific aims of this research are: 1) to develop an improved Adolescent AFIX (Assessment, Feedback, Incentives, and eXchange) consultation; 2) to assess the impact of consultations delivered in two modes, in-person and webinar, on providers' use of immunization best practices and adolescents' vaccination status; and 3) to assess the feasibility of Adolescent AFIX for state health department personnel and vaccine providers. 

The research team works in partnership with state health department immunization specialists in three states (Illinois, Michigan, and Washington) to deliver information about HPV vaccination to providers, encourage strong recommendations for vaccination, and provide ongoing feedback to providers about their clinics’ immunization rates via an HPV immunization report card. For each state, a simple randomization is used in a 1:1:1 ratio to assign clinics with at least 500 adolescent patients to receive an in-person AFIX consultation, a webinar consultation, or no consultation. For this pragmatic clinical trial, the sample size was based on the number of AFIX consultations that many state health departments can deliver in a 6-month period.




Research Areas


PIs: Noel T. Brewer, Ph.D., M.S. and Melissa B. Gilkey, Ph.D., M.P.H.
Project Manager: Jennifer MacKinnon, University of North Carolina